Emergency services were called to the A158 at Burgh Le Marsh at 7:53am this morning (Friday) after a white Fiesta van and a blue Fiat Punto were involved in a collision.
The driver of the Fiesta, an 18 year-old man from Skegness, was taken to Boston Pilgrim Hospital by air ambulance, suffering from a serious head injury.
The driver of the Punto, believed to be a 31 year-old Horncastle woman, has gone to Skegness Hospital with minor injuries.
The road is currently closed with diversions in place.
Anyone who witnessed the collision or who saw the vehicle prior to the incident should contact the Collision Witness Hotline on 01522 558855.
Update (16/01/2012): Sadly, the 18 year old man involved in the accident as died.